Cannabidiol (CBD) is usually the second-most common cannabinoid in weed, the first being tetrahydrocannabinol (THC). That being said, most weed has such a small content of CBD that it makes little to no difference.

And yet CBD shows promise as a treatment for 15 distinct health problems, both emotional as well as directly physical

But it couldn’t be more different from THC. Instead of providing a high, cannabidiol provides a ground. Most studies suggest that THC and cannabidiol work opposite in almost all respects.

CBD has many mechanisms. It acts on serotonergic, glutamatergic, opioidergic, and cannabinoid receptors. Recently, an experiment has concluded that it’s a partial agonist at D2 (a subtype of the dopamine receptor), which is the antipsychotic mechanism of the antipsychotic Abilify (aripiprazole).  Body-Chemical Basics can assist in understanding the sceintific jargon.

Types of Neurotransmitters, Psychoactive Effects of Receptor-Binding, and The Basics of Brain Cells, offer information. The other scientific sections are less relevant, but nonetheless interesting!

Please refer to Principles of Qualified Sources, which I am linking here because I claim a very high magnitude of benefit of CBD.

The studies below detail the major findings of CBD against various illnesses. Some of the entries are followed by numbers in parentheses. This means that multiple studies found the given effect. For example: depression (3) would mean that three studies found cannabidiol significantly effective against clinical depression.

Again, these are illnesses that CBD works against, ranked by frequency…

  1. Directly emotional
    1.  Psychosis, with fewer side effects (9)
    2. Clinical anxiety (5)
    3. Neurotoxicity (4)
    4. Treatment-resistant epilepsy (2)
    5. Depression (2)
    6. Drug addiction
    7. Cataplexy
    8. Insomnia
  2. Directly physical
    1. Pain (2)
    2. Inflammation
    3. Bowel incontinence
    4. Cancer
    5. Blood vessel tension
    6. Hypoxia
    7. Cardiovascular diseases

Below is elaboration, and links to the studies finding use against the harms above.

  • A review on cannabidiol discovered many benefits
    • Frequent efficacy for types of severe, treatment-resistent epilepsy
    • Greater improvement of positive, negative, and cognitive symptoms of schizophrenia, in two different models of psychosis, with fewer side effects, than a pharmaceutical antipsychotic
    • Function as an anxiolytic (anxiety-reducer) by the results of many tests
    • Reduces recreational drug use, such as inhibiting heroin-seeking for at least two weeks
  • This systematic review also found several positive traits
    • A remakable lack of uncomfortable side effects, even up to doses up to 1500 mg
    • Opposite effects as THC in brain regions associated with psychosis
    • More CBD in marijuana=less incidence of psychotic reaction
    • It has antipsychotic action as studies have found (2014), but more need to be conducted
  • Was found to improve the symptoms of those who battle social anxiety disorder
  • Can treat various motor-related disorders, such as cataplexy
  • A systematic review discovered antioxidant effects and neuroprotection againt THC-induced damage to the hippocampus
  • Treats depression, anxiety,and psychosis
  • Similar to atypical antipsychotics in treating psychosis, with few side effects
  • A systematic review in the human population discovered that CBD counters the cognitive and psychotic effects of THC, and furthermore can possibly prevent psychotic illness created by THC
  • Reduces psychotic effects of THC, according to Cambridge University
  • Neuroprotective effects in the hippocampus
  • Stops THC-induced paranoia and memory impairments
  • Effective against psychosis in parkinson’s disease
  • Weed with higher levels of cannabidiol led to fewer psychotic episodes
  • Reduces psychotic symptoms of schizophrenia
  • Decreases anxiety for people with social phobia
  • Improves anxiety  in a similar way as, buspirone, the pharmaceutical prescribed for anxiety
  • This relatively recent review proposed a plethora of potential health applications, some of which don’t directly affect mental well-being. But they do so indrectly, so are thus included.
    • Anti-inflammatory in many ways, such as in the retina of the eye
    • Treats significant involuntary movement of intestinal muscles
    • Functions as an analgesic after nerve damage and inflammation
    • Can enhance effects of other painkillers
    • Works to selectively destroy various cancers
    • Has antipsychotic properties
    • Can promote sleep
    • Reduces tension on the walls of blood vessels
    • Promotes the healing an maintenance of cells that store energy and create hormones
    • Prevents various tissue from being cut off from oxygen and nutrients
    • Is likely neuroprotective
    • Has anti-epileptic properties
    • Can act as an antidepressant
    • Slows down or stops the development of cardiovascular disease

Sooner or later, cannabidiol, and cannabinoids in general, will find their way to the market. Already, back in March 2016, positive results were found in advanced clinical trials for cannabidiol in treating a rare form of epilepsy., though bias, has some interesting information to chew on.


Sources: Ben Komor Dr. Henry Gerson, Dr. Theodore Papperman, Dr. John Bezirganian,